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Hi,
SAS is just another protocol like FC DAS etc. As long as the target complies to a spec that the initiator understands and VMware supports the initiator and target your OK. I would not use SAS for this application.
iSCSI will handle that load very easily, what you need to be concerned about is the amount of IO load. Two or three servers and 50 users is very small. I have 25 servers running on 1 ESX host in development running over 2 x 1GB QLA4050c cards. No issues at all.
Regards,
Mike
vExpert 2009
http://blog.laspina.ca/
vExpert 2009