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I am always extra careful when it comes to virtualising TS boxes. I stick to the following recommendations:
Use 2vCPU per VM
Run no more than 1 vCPU per pCPU, or 1.5 as an absolute maximum
Create 3 VMDK, One for System, one for a pagefile (2x RAM) on the fastest disk possible, and one for applications
ENsure all partitions are aligned to 64KB blocks
Use 64-bit Windows and give it plenty of RAM
Do not overcommit memory, in fact disable memory sharing on the VMs
If you still get issues then its time to resort to splitting applications between different TS servers and split those between hosts (not nice)