iw123
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Commander

As said in previous posts, it's not so much an upgrade as a migration due to the move to 64bit only OS for vcenter etc and the fact that vSphere 5 is ESXi only.  Depending on your infrastructure, it should be possible to do it without downtime to virtual machines however.

*Please, don't forget the awarding points for "helpful" and/or "correct" answers
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