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Thanks for the information about the TLB and the BIOS recommendations. There are two VMWare KB's which I have been referred to which are fixed in a recent ESX 5.5 patch
These are included in the post 5.5 U2 patch below:
VMware KB: VMware ESXi 5.5, Patch ESXi-5.5.0-20141004001-standard
We're going to try both and see what happens. Also, please note that although the TLB ACK invalidate has been consistently referred to as a hardware related problem (CPU not responding) in my support cases, there are some VMWare documents that clearly state that the CPU can go into a non-responsive state for an extended period due to an ESXi software issue as well.