I didn't know of these metrics. Just watching hit here, I don't see anything for this VM:

PORT-ID USED-BY TEAM-PNIC DNAME PKTTX/s MbTX/s PKTRX/s MbRX/s %DRPTX %DRPRX

50331831 27214:hostname vmnic6 vSwitch2 23.65 0.07 21.74 0.01 0.00 0.00

I have been watching the following items pretty close from a physical monitoring host:

-firewall

-esx host (management interface)

-vm guest

-another physical host

The only one that seems to jump to higher RTAs (>10ms) is the vm guest. Everything else stays < 1 ms for the most part. Every once in a great while something will jump to 1.xx ms but its rare. Again, pretty crude but at least I am seeing consistency. So I think I am on the right track by digging into the VM side at least but need to find the metrics that point to the issue.