ESXi has a version of Python installed:

[root@esxi:~] python -VV
Python 3.8.8 (default, Oct 13 2021, 02:13:52)
[GCC 4.6.3]
[root@esxi:~] vmware -vl
VMware ESXi 7.0.3 build-19193900
VMware ESXi 7.0 Update 3

What you shouldn't try to do is install updates or additional modules. ESXi is not a general purpose operating system and changes like that are unsupported. Also, you'd need to update via VIB, reduce the acceptance level etc.