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Restarting the vCenter service or rebooting the vCenter server didn't fix this? It sounds like a problem communicating via vpxuser on the machine. Rebooting your vCenter won't affect running VMs on individual hosts in any way.
I'm assuming you don't have HA running or have configured the isolation response to be "Leave VMs Powered On"
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Shane Wendel, VCP
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Shane Wendel
VCP: vSphere 4
VCP: VI3
http://fatalsync.wordpress.com