These commands only work for a standalone host and not for hosts attached to vcenter.

esxcli system settings advanced set -o /Mem/HostLocalSwapDir –s “Path to datastore”

esxcli system settings advanced set -o /Mem/HostLocalSwapDirEnabled -i 1

These commands are not applicable for applying to host profiles.

Once you add it to vCenter, the Host local SwapDir Enabled value becomes 0.