In a Guest OS level, you can repeat the operation made on the physical world with no problem. Veeam backups (or VCB/VDR ones) are always welcome in a VM image fashion. If you can have a combination of both (for disaster recovery) you will be doing good.
Marcelo Soares
VMWare Certified Professional 310/410
Technical Support Engineer
Globant Argentina
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Marcelo Soares