If that's not an x86-based HP system, then no - ESXi is not an emulator and can only run x86-based VMs.
This link may help you: https://community.hpe.com/t5/System-Administration/Can-I-create-a-VMware-Virutal-HP-UX-server/td-p/4...
Hi,
Re: Can we install HP UX virtual machines on VMware
1) Can we install HP UX on top of VMware, if we use an RX series server?.
No, VMWare does not run on ia64.
You need to use HPVM - Integrity Virtual machines. IA64 servers use ARIES to execute RISC based code.
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Vmware don't support cpu itanium.
VMware Compatibility Guide - System Search
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in the attached:
HP-UX 11i compatibility for HPE Integrity and HP 9000 servers
Compatibility within HP-UX 11i Virtualization solutions
Well-behaved applications built on HP-UX 11i are binary compatible to run within HPE Virtual Partitions (vPars) on the same architecture family. No changes, recompilation, or recertification is necessary.
Well-behaved applications built on HP-UX 11i Integrity are binary compatible to run within an HPE Integrity Virtual Machine. This binary compatibility applies to applications with no specific device dependencies (most applications) and to applications that depend only on devices currently virtualized by HPE Integrity VM.
ARomeo