Hello.
The patch and update packages in VMware vSphere are cumulative.
Attached link about the versions of vCenter Server Appliance
https://kb.vmware.com/s/article/2143838
In practice, it is usually recommended to use the penultimate and not the last one available. If it is not mandatory to apply the latest one due to a specific problem.
Another rule of thumb is to always have a full backup.
Enrique Espinel
Senior Technical Support IBM, Lenovo, VMware vSphere and Veeam Backup.
VMware VSP-SV, VTSP-SV, VTSP-HCI, VTSP 5
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