Yes I have seen this, it has to do with the backups and the vmkernel still has the lock on the file from the backup.. sometimes because of a vmotion during backup.. or other circumstances.
You will need to verify backuops are complete, and see which host has the file lock and restart management services on the ESX host. and that will release the lock, sometimes I have had to restart management services on every host in the cluster before I could do anything with the files.
This happens with other vendors also. Seems to be more prevalent in busy systems doing allot of storage vmotions during backup windows.
Thank You.
Mike Masters