IF you are referring to refresh storage there is no issues.
if you referring to rescan storage , there are no issues.
but none of them help to keep drives mapped.
rescan storage is done to discover new devices/LUNs attached -- if any
refresh storage can be used to refresh the capacity info if you have deleted or added new items on the datastore
Once configured.. there is no reason why any drive instances would go inactive.. unless you have removed them manually or there are underlying storage issues