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Deploy VM from Template; Customization Profile new SID or SysPrep

ESXi 6.5 in our environment.  I'm putting the final touches on a new Windows Server 2019 VM that will be converted to a template to be used for all new servers going forward.  All the VMs created from this template will be domain-joined.  Can I create a basic Customization Profile with "Generate new SID" checked to be used in conjunction with creating new VMs from the above template, or do I need to run SysPrep on the newly created VM after it starts up for the first time?  I've researched this and there are so many opinions, but I remember reading somewhere that for domain-joined servers, only the SID needs to be unique.  Any confirmation to this or other ideas?

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