After applied Windows Update (KB4012212) in Windows Server 2008 R2 x64 with the vCenter, the vSphere client does not connects to vCenter (localhost) with error message:
"An unknown connection error occurred. (The request failed due to an SSL error. (The request was aborted: Could not create SSL/TLS secure channel.))"
Any vSphere and web client from machines with the Windows Updates to fix SMBv1 vulnerability cannot connect to vCenter 5.1.0 (for e.g. build-880146).
The Web client is still working, but only in localhost.