Hello,
The patch does apply for the VCSA Devices.
Refer the following for more details :
VMSA-2021-0010: What You Need to Know :
https://blogs.vmware.com/vsphere/2021/05/vmsa-2021-0010.html
How to Disable VMware Plugins in vCenter Server : Disable vCenter Server plugins on Linux-based virtual appliances (vCSA)
https://kb.vmware.com/s/article/83829
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