vCenter will know that there are multiple clusters.
Only other thing is to plan out how much I/O each of the VM's in both clusters will be using and make the datastores can handle that much I/O.
Make sure that you have alerts turned on for storage space so you are aware when space is getting low.
I have multiple clusters using the same datastores with no issues.
Please do not forget to mark helpful or correct answers.
Marc
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Thanks,
Marc Crawford
CCNA, MCSE, MCTS, A+, Net+, Sec +, VCA-WM, VCA-DCV, VCA-Cloud, VCA-NV, VCP-NV, VCP-DCV, VCP, VCAP5-DCA
http://gplus.to/marccrawford
http://blog.marccrawford.com
@uber_tech_geek