Is it possible to have
Host: Windows 10
CTRL+ALT+DELETE: Disabled
Client: Windows 2000
CTRL+ALT+DELETE: Enabled
This is needed as the users on the client can log off and another user log on.
This is needed
No is not, since you can use the menu => virual machine => send Ctrl+Alt+Del
Otherwise
https://www.google.com/search?client=firefox-b-d&q=windows+10+disable+Ctrl%2BALt%2BDel
In addition to the menu option mentioned above, you use the key combination Ctrl-Alt-Ins to send Ctrl-Alt-Del to a guest VM.