Well I am not sure if there are any datastore forums or strategies, the best tool I found for this purpose is du -h. This will list the directory / files and show the size in easy to read format, and you can see how big the folders are, and easily see the name.
Run this command while viewing /vmfs/volumes/
Then for cleanup in each VM, I would advise that you keep the VM running while you prune the directories, this is to ensure that while the VM is keeping the files open, you don't accidentally delete needed files.
Other than that, the VMFS is like cleaning up a file server, or any other data drive, you pretty much have to keep up with it on a monthly basis.