Hi,
Does ESX have any issues if this is done?
4 Port Nic, trunked into Cisco Catalyst...
If you use IP hash routing on ESX, you must have your physical switch configure with Etherchannel
Else, if the routing is done by Port ID or MAC hash you must desable all teaming protocol like Etherchannel
Refer to
here a document from Cisco, how to configure VMware with Cisco.