If it's a setting you can apply under the "Regional And Language" Windows Control Panel Applet, then I would speculate you might be able to virtualize it with ThinApp as ThinApp can isolate language and locale info (since these are generally per user type of settings). If, however, it's something you have to do at the system/kernel level, then I would say most likely no.
Hope this helps,
-Dean F.
http://pubs.vmware.com/thinapp4/help
-Dean F.
https://www.vmware.com/support/pubs/identitymanager-pubs.html