Yes you can as per doc VMware Documentation Library - How Site Recovery Manager Computes Datastore Groups
Site Recovery Manager aggregates datastores into datastore groups to accommodate virtual machines that span multiple datastores. Site Recovery Manager regularly checks and ensures that datastore groups contain all necessary datastores to provide protection for the appropriate virtual machines. When necessary, Site Recovery Manager recalculates datastore groups.
Site Recovery Manager combines devices into datastore groups according to set criteria.
- Two different datastores contain files that belong to the same virtual machine.
- Multiple datastores belong to a consistency group. A consistency group is a collection of replicated datastores where every state of the target set of datastores existed at a specific time as the state of the source set of datastores. Informally, the datastores are replicated together such that when recovery happens using those datastores, software accessing the targets does not see the data in a state that the software is not prepared to deal with.
Protecting Virtual Machines on VMFS Datastores that Span Multiple LUNs or Extents
Not all SRAs report consistency group information from the storage array, because not all storage arrays support consistency groups. If an SRA reports consistency group information from the array following a datastore discovery command, the LUNs that constitute a multi-extent VMFS datastore must be in the same storage array consistency group. If the array does not support consistency groups and the SRA does not report any consistency group information, Site Recovery Manager cannot protect virtual machines located on the multi-extent datastore.
This blog post has also a good explanation on SRM protection group
SRM Protection Group Design Considerations - VMware vSphere Blog
Bayu Wibowo | VCIX6-DCV/NV
Author of VMware NSX Cookbook http://bit.ly/NSXCookbook
https://github.com/bayupw/PowerNSX-Scripts
https://nz.linkedin.com/in/bayupw | twitter @bayupw
