Horizon connection servers are deployed in pods. One or more vCenters per pod is best practice. The connection servers have a strict LAN requirement for AD LDS replication so you will need to create a different pod per site. I'd advise looking into Cloud Pod to link the data centers.
Horizon Connection Server Maximums and Virtual Machine Configuration
Connection Server Cluster Design Considerations
You can deploy multiple replicated Connection Server instances in a group to support load balancing and high availability. Groups of replicated instances are designed to support clustering within a LAN-connected single-datacenter environment.
Important:
To use a group of replicated Connection Server instances across a WAN, MAN (metropolitan area network), or other non-LAN, in scenarios where a Horizon deployment needs to span datacenters, you must use the Cloud Pod Architecture feature. You can link together 25 pods to provide a single large desktop brokering and management environment for five geographically distant sites and provide desktops and applications for up to 50,000 sessions. For more information, see the Administering Cloud Pod Architecture in Horizon 7 document.
Cloud Pod Architecture Overview