The great thing about Persona Management apart from Roaming Profiles on standard desktops is that your desktops do not have to traverse the LAN (or WAN) for redirection because the desktops are located in the virtual data center. If your shares are mounted on a VM inside the same host on a vSphere host version 5.0, you can get 1MM IOPS with the right hardware! (That should be enough response for redirection). If you are traversing vSwitch or DvSwitch, you still have very little latency regardless of the storage type if you are using shares on a VM with a mounted NFS volume or iSCSI/FC LUN. CIFS works great but you might also consider using a dedicated NFS or iSCSI ethernet network (VLAN) for your mounted NFS volumes or iSCSI mapped LUNS that are on the same ethernet switch as your hosts, preferably in a trunk. A design like this ensures maximum throughput and reduced contention unlike a CIFS share generally presented to the users' production network. If the dedicated ethernet network must be accessible to DNS and Active Directory (publishing CIFS in AD), you can do that with a router and reserve all of that high speed bandwidth for dedicated IP storage traffic.
