vSphere Replication with large VMs?

Does anyone have any experience of replicating large VMs such as a 10TB virtualised file server or Exchange 2010 with a couple of TB of datastores?

I'm looking at how we can replicate for DR purposes and I suspect I may be a little stuck in the past and these aren't actually "large" any more by VMware standards, but unfortunately right now I don't have a destination with enough free space to actually try it out.


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