DirectPath I/O shouldn't have anything to do with USB - it's available to pass PCI devices into VMs.
USB HIDs (such as keyboards or mice) can be problematic with USB passthrough. See KB 1021345 (http://kb.vmware.com/selfservice/microsites/search.do?language=en_US&cmd=displayKC&externalId=1021345)
If the device isn't listed in that article, it may not be possible to pass through at this time.
Thanks,
-jk