Running ESXi 6.0.0 2494585 on a Dell PowerEdge R610.
The problem I have with this machine is that, every so often, about once a month, but sometimes more frequently like once a week, I will lose all network communication with this machine.
The 4 built-in NICs will stop repsonding, and I have to reboot the machine to get everything running again.
It is not a hard lock, because I can still access ESXi from the console, and it reports that all the NICs are working fine (ha).
I have another R610 with identical hardware configuration and same version of ESXi, and this problem almost never happens (I say "almost" because maybe I did have a similar problem once in a year?).
Thinking it was maybe a hardware issue, I replaced the motherboard (which includes the onboard NICs) on the problematic R610, but the problem continued.
I have no idea how I would start to go about troubleshooting this problem. Any ideas?