You mean hard-drives with 4kB sector-size? Yes, vSphere 5.1 does support it (I have one such a drive for local backups). It should not be any problem for VMFS5 filesystem because it uses block/sub-block size 1MB/8kB. So on vSphere-side you are OK...
But check if your disk/raid-controller supports drives with 4kB sector-size! Some older might not support it yet (at least not those that can not emulate 512B sectors)...
_____________________________________________
If you found my answer useful please do *not* mark it as "correct" or "helpful". It is hard to pretend being noob with all those points! 😉