Today we had a major outage after rescanning the datastore. Out of 7 blade server, we had lost the datastore in 5 blades.
I had to reboot all the hosts one by one to resolve this issue.
ESXi Version: 7.0 u1
Blader Server: HP Synergy
Validate your physical storage, check if you have alarms or warnings on the LUNs that are configured on the hosts.
Adicioanl generates a vm-support to validate logs of the entire virtualized platform.
If you download the logs, you can share them for review.