Hi KBetter
Windows cannot see VMFS datastores directly. VMFS is the datastore where you will store VM files (hard disk files, configuration file, nvram, etc.). The VMFS block size will determine a maximum hard disk size. For example, if you use a block size of 8 MB, your guest VM will use a disk 2048GB maximum.
Windows guest will see "inside" vmdk file stored in a VMFS datastore. This vmdk file could be formatted with any file system, with any block size.
Your guests vms are entirely encapsuled in files and cannot access directly VMFS datastores. (ok, you can do this using iscsi drivers for windows.... , but this is a work around).
Take care.