I want to return to this as I think there may be some light at the end of the tunnel and an opportunity to turn this into a learning exercise :).
I recovered some of the VMs from the backups, which I restored to another data store, so that was good. However, on the problem data store, I was able to scan for potentially lost VMDKs, which seemed to indicate that there might be something to recover. I used a trial version of "DiskInternal VMFS Recovery", which showed the following, although to recover items would require a $999 license, so beyond the scope of this exercise:
I also created a VMFS-Header-dump (using this article - https://communities.vmware.com/t5/VMware-vSphere-Documents/Create-a-VMFS-Header-dump-using-an-ESXi-H...), and extracted some stuff that can at least be read, albeit, I don't know what can be done with the data (if anything):
Again, this may be wishful thinking, but as I am not using this data store for anything else, so I have time to see what might be possible.
Any thoughts from anyone?