Theres no real performance difference for the various blog sizes, and all guest writes are passed through to the underlying device, so the 4MB block size doesn't really matter.
My guess is that they suggest 4MB as a standard for their cards because their largest card is 640GB and a 4MB bock size would allow one to create maximum sized VMDK on a cad of that size (1TB would be the limit for a 4MB block size).
--Matt
VCDX #52
blog.cowger.us