I'm curious however to know if anyone has tried using a datastore larger than 1TB.
go back and read the setup guide. The 1TB is NOT a recommendation it's a LIMITATION of the VDR. It's not supported, so yes you MUST keep it to 1TB or less.. or have fun fixing issues. It's also limited to ONLY 2 datastores, and each one must be 1TB or less.
It's really nice to see VDR growing up, but unless I can backup my entire infrastructure.
You can have more than 1 VDR in your environment, but you can't have more than 100 VM's PER VDR.
I don't want to be managing multiple VDR instances
Well it looks like you won't be using VDR then . . . . . .