To add to this thread (although our issue is not exactly the same as the original poster's), we had major issues upgrading from SEG classic to V2.
Immediately after upgrading, we've noticed issues sending email with attachments (or perhaps just large emails) that get worse with time (1-2 hours). The fix was to bounce the server/services. AW support has not been very helpful in diagnosing the issue. Receiving has not been an issues at all.
We gave up after struggling with it for 4 days.
We rolled back to classic and it's been stable since.