If the sctarch locaction is configured to point to LUN, and this LUN disappear, ESXi 5 gets a fit & disconnects from VC (and can not be administered any more)
The VMs still run (can be acceessed directly), but they can NOT be migrated
esxcli on the server does NOT work any more (it gives Connection Failure to localhost)
The only option is to reboot the affected ESXi (switching off the VMs first by their own means)
"Tested" it on 3 ESXi
I think there should be a failsafe build in, so if the locaction is not there any more then it reverts back to /tmp/scratch
Seb