We use Veeam Backup and Replication with the combination of ArcServe Replication and High Availability. The issue with veeam is that it cannot see "pass-through disks" and that is why we combined it with Arcserve. But overall, Veeam works very well with our environment. It even has the capability to point to your vCenter and gather all the vm's registered on it. Pretty neat for me. 
*note, I also do not promote Veeam nor Arcserve. We actually have 3 layers of protection, the last layer is Microsoft Data Protection Management (DPM). 
This one is providing nice backup facalities...
ShadowProtect Server provides the following backup and disaster recovery benefits:
- Rapidly recover data.
- Recover to similar or dissimilar hardware and/or to and from virtual environments.
- Centralized backup administration from a management console.
- ShadowControl® ImageManager™ to automatically consolidate backup image files.
- Verification and re-verification of backup images.
- VirtualBoot technology for quick failover to a virtual server.
- Converter tool to convert to .VHD or .VMDK.
- Automatic backup of SQL, Exchange, SharePoint, CRM and other critical applications.
- Granular recovery of individual files and folders in moments.
- Simplified migration to new Windows servers.
- Scheduler for automatic full and incremental backups.
Regards,
Milton 
Yeah. What I liked about Veeam is how it is optimized for off-site DR replication and throttling of replication speed through WAN.
