You shouldn't be looking for a process using up CPU cycles, you should be looking for a process or VM doing heavy disk, network, or memory writes. I/O wait is the percentage of CPU cycles spent waiting on something else to occur - usually disk transactions. The following process is a bit odd:
root 11645 11266 0 2008 ? 00:00:00
Were you doing something on the service console with vmkfstools? If so, it looks like it may have hung up. Also, you have several copies of the vmbackup script running, along with several defunct crond processes. I'm going to guess your backup routine/script is not working properly, and this is probably at least one of the things contributing to the high I/O wait. Unfortunately, you probably have a process hung on I/O, which are very, very difficult to get rid of. If you're running a cluster, it's time to migrate your VMs over to the other ESX machine and reboot. Then you'll want to spend some time figuring out why your backup script never exits properly.
