Thanks for the quick reply. So without the connection broker being used, does that mean the only method of USB redirection is to use some sort of third party software? Does that kind of software install on the virtual machine or the thin client? I think HP does offer something like this, but I have to check. We are stuck using HP because the thin clients have already been purchased.

What we are planning is simple thumbdrive and external CD drive use through the USB ports on a few of our HP 5145 thin clients. We will be connecting to our desktop VM's using RDP and from what I've been able to gather, those simple uses should be supported by RDP alone. No need for connection broker, VDI agent, or third party software solution. If we decide to connect something more complex like a scanner, then we probably will need to use something like third party software like AnywhereUSB that you suggested. Am I on the right track here? Thanks.